The Alaska Antimicrobial Stewardship Collaborative is an active partnership of acute care and long-term care hospitals dedicated to developing innovative strategies to ensure appropriate antibiotic use. A2SC’s goal is a simple one: all patients in Alaska will receive the right antibiotic at the right time and only when necessary. While at one time, antibiotics revolutionized the practice of medicine by providing a rapid cure to many illnesses that were once fatal, those days may soon be gone. The emergence of antibiotic-resistant bacteria caused by the misuse and overuse of antibiotics is pushing the healthcare industry to re-evaluate how medicine is practiced. Together we will accelerate positive changes to achieve this critical goal.